124 research outputs found
The Galactic Center Black Hole Laboratory
The super-massive 4 million solar mass black hole Sagittarius~A* (SgrA*)
shows flare emission from the millimeter to the X-ray domain. A detailed
analysis of the infrared light curves allows us to address the accretion
phenomenon in a statistical way. The analysis shows that the near-infrared
flare amplitudes are dominated by a single state power law, with the low states
in SgrA* limited by confusion through the unresolved stellar background. There
are several dusty objects in the immediate vicinity of SgrA*. The source G2/DSO
is one of them. Its nature is unclear. It may be comparable to similar stellar
dusty sources in the region or may consist predominantly of gas and dust. In
this case a particularly enhanced accretion activity onto SgrA* may be expected
in the near future. Here the interpretation of recent data and ongoing
observations are discussed.Comment: 30 pages - 7 figures - accepted for publication by Springer's
"Fundamental Theories of Physics" series; summarizing GC contributions of 2
conferences: 'Equations of Motion in Relativistic Gravity' at the
Physikzentrum Bad Honnef, Bad Honnef, Germany, (Feb. 17-23, 2013) and the
COST MP0905 'The Galactic Center Black Hole Laboratory' Granada, Spain (Nov.
19 - 22, 2013
Impaired recognition and regulation of disgust is associated with distinct but partially overlapping patterns of decreased gray matter volume in the ventroanterior insula
Background The ventroanterior insula is implicated in the experience, expression, and recognition of disgust; however, whether this brain region is required for recognizing disgust or regulating disgusting behaviors remains unknown. Methods We examined the brain correlates of the presence of disgusting behavior and impaired recognition of disgust using voxel-based morphometry in a sample of 305 patients with heterogeneous patterns of neurodegeneration. Permutation-based analyses were used to determine regions of decreased gray matter volume at a significance level p <=.05 corrected for family-wise error across the whole brain and within the insula. Results Patients with behavioral variant frontotemporal dementia and semantic variant primary progressive aphasia were most likely to exhibit disgusting behaviors and were, on average, the most impaired at recognizing disgust in others. Imaging analysis revealed that patients who exhibited disgusting behaviors had significantly less gray matter volume bilaterally in the ventral anterior insula. A region of interest analysis restricted to behavioral variant frontotemporal dementia and semantic variant primary progressive aphasia patients alone confirmed this result. Moreover, impaired recognition of disgust was associated with decreased gray matter volume in the bilateral ventroanterior and ventral middle regions of the insula. There was an area of overlap in the bilateral anterior insula where decreased gray matter volume was associated with both the presence of disgusting behavior and impairments in recognizing disgust. Conclusions These findings suggest that regulating disgusting behaviors and recognizing disgust in others involve two partially overlapping neural systems within the insula. Moreover, the ventral anterior insula is required for both processes
Radiating Shear-Free Gravitational Collapse with Charge
We present a new shear free model for the gravitational collapse of a
spherically symmetric charged body. We propose a dissipative contraction with
radiation emitted outwards. The Einstein field equations, using the junction
conditions and an ansatz, are integrated numerically. A check of the energy
conditions is also performed. We obtain that the charge delays the black hole
formation and it can even halt the collapse.Comment: 22 pages, 9 figures. It has been corrected several typos and included
several references. Accepted for publication in GR
Coordinated multi-wavelength observations of Sgr A*
We report on recent near-infrared (NIR) and X-ray observations of Sagittarius
A* (Sgr A*), the electromagnetic manifestation of the ~4x10^6 solar masses
super-massive black hole (SMBH) at the Galactic Center. The goal of these
coordinated multi-wavelength observations is to investigate the variable
emission from Sgr A* in order to obtain a better understanding of the
underlying physical processes in the accretion flow/outflow. The observations
have been carried out using the NACO adaptive optics (AO) instrument at the
European Southern Observatory's Very Large Telescope (July 2005, May 2007) and
the ACIS-I instrument aboard the Chandra X-ray Observatory (July 2005). We
report on a polarized NIR flare synchronous to a 8x1033 erg/s X-ray flare in
July 2005, and a further flare in May 2007 that shows the highest sub-flare to
flare contrast observed until now. The observations can be interpreted in the
framework of a model involving a temporary disk with a short jet. In the disk
component flux density variations can be explained due to hot spots on
relativistic orbits around the central SMBH. The variations of the
sub-structures of the May 2007 flare are interpreted as a variation of the hot
spot structure due to differential rotation within the disk.Comment: 15 pages, 7 figures, contribution for the conference "The Universe
under the Microscope" (AHAR 2008), to be published in Journal of Physics:
Conference Series by Institute of Physics Publishin
The genomes of two key bumblebee species with primitive eusocial organization
Background: The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies. Bumblebees are also invaluable natural and agricultural pollinators, and there is widespread concern over recent population declines in some species. High-quality genomic data will inform key aspects of bumblebee biology, including susceptibility to implicated population viability threats. Results: We report the high quality draft genome sequences of Bombus terrestris and Bombus impatiens, two ecologically dominant bumblebees and widely utilized study species. Comparing these new genomes to those of the highly eusocial honeybee Apis mellifera and other Hymenoptera, we identify deeply conserved similarities, as well as novelties key to the biology of these organisms. Some honeybee genome features thought to underpin advanced eusociality are also present in bumblebees, indicating an earlier evolution in the bee lineage. Xenobiotic detoxification and immune genes are similarly depauperate in bumblebees and honeybees, and multiple categories of genes linked to social organization, including development and behavior, show high conservation. Key differences identified include a bias in bumblebee chemoreception towards gustation from olfaction, and striking differences in microRNAs, potentially responsible for gene regulation underlying social and other traits. Conclusions: These two bumblebee genomes provide a foundation for post-genomic research on these key pollinators and insect societies. Overall, gene repertoires suggest that the route to advanced eusociality in bees was mediated by many small changes in many genes and processes, and not by notable expansion or depauperation
Reaction rates and transport in neutron stars
Understanding signals from neutron stars requires knowledge about the
transport inside the star. We review the transport properties and the
underlying reaction rates of dense hadronic and quark matter in the crust and
the core of neutron stars and point out open problems and future directions.Comment: 74 pages; commissioned for the book "Physics and Astrophysics of
Neutron Stars", NewCompStar COST Action MP1304; version 3: minor changes,
references updated, overview graphic added in the introduction, improvements
in Sec IV.A.
The quest for the solar g modes
Solar gravity modes (or g modes) -- oscillations of the solar interior for
which buoyancy acts as the restoring force -- have the potential to provide
unprecedented inference on the structure and dynamics of the solar core,
inference that is not possible with the well observed acoustic modes (or p
modes). The high amplitude of the g-mode eigenfunctions in the core and the
evanesence of the modes in the convection zone make the modes particularly
sensitive to the physical and dynamical conditions in the core. Owing to the
existence of the convection zone, the g modes have very low amplitudes at
photospheric levels, which makes the modes extremely hard to detect. In this
paper, we review the current state of play regarding attempts to detect g
modes. We review the theory of g modes, including theoretical estimation of the
g-mode frequencies, amplitudes and damping rates. Then we go on to discuss the
techniques that have been used to try to detect g modes. We review results in
the literature, and finish by looking to the future, and the potential advances
that can be made -- from both data and data-analysis perspectives -- to give
unambiguous detections of individual g modes. The review ends by concluding
that, at the time of writing, there is indeed a consensus amongst the authors
that there is currently no undisputed detection of solar g modes.Comment: 71 pages, 18 figures, accepted by Astronomy and Astrophysics Revie
e-Science and biological pathway semantics
<p>Abstract</p> <p>Background</p> <p>The development of e-Science presents a major set of opportunities and challenges for the future progress of biological and life scientific research. Major new tools are required and corresponding demands are placed on the high-throughput data generated and used in these processes. Nowhere is the demand greater than in the semantic integration of these data. Semantic Web tools and technologies afford the chance to achieve this semantic integration. Since pathway knowledge is central to much of the scientific research today it is a good test-bed for semantic integration. Within the context of biological pathways, the BioPAX initiative, part of a broader movement towards the standardization and integration of life science databases, forms a necessary prerequisite for its successful application of e-Science in health care and life science research. This paper examines whether BioPAX, an effort to overcome the barrier of disparate and heterogeneous pathway data sources, addresses the needs of e-Science.</p> <p>Results</p> <p>We demonstrate how BioPAX pathway data can be used to ask and answer some useful biological questions. We find that BioPAX comes close to meeting a broad range of e-Science needs, but certain semantic weaknesses mean that these goals are missed. We make a series of recommendations for re-modeling some aspects of BioPAX to better meet these needs.</p> <p>Conclusion</p> <p>Once these semantic weaknesses are addressed, it will be possible to integrate pathway information in a manner that would be useful in e-Science.</p
Motor signatures of emotional reactivity in frontotemporal dementia
Automatic motor mimicry is essential to the normal processing of perceived emotion, and disrupted automatic imitation might underpin socio-emotional deficits in neurodegenerative diseases, particularly the frontotemporal dementias. However, the pathophysiology of emotional reactivity in these diseases has not been elucidated. We studied facial electromyographic responses during emotion identification on viewing videos of dynamic facial expressions in 37 patients representing canonical frontotemporal dementia syndromes versus 21 healthy older individuals. Neuroanatomical associations of emotional expression identification accuracy and facial muscle reactivity were assessed using voxel-based morphometry. Controls showed characteristic profiles of automatic imitation, and this response predicted correct emotion identification. Automatic imitation was reduced in the behavioural and right temporal variant groups, while the normal coupling between imitation and correct identification was lost in the right temporal and semantic variant groups. Grey matter correlates of emotion identification and imitation were delineated within a distributed network including primary visual and motor, prefrontal, insular, anterior temporal and temporo-occipital junctional areas, with common involvement of supplementary motor cortex across syndromes. Impaired emotional mimesis may be a core mechanism of disordered emotional signal understanding and reactivity in frontotemporal dementia, with implications for the development of novel physiological biomarkers of socio-emotional dysfunction in these diseases
Differential Spatial Expression and Subcellular Localization of CtBP Family Members in Rodent Brain
C-terminal binding proteins (CtBPs) are well-characterized nuclear transcriptional co-regulators. In addition, cytoplasmic functions were discovered for these ubiquitously expressed proteins. These include the involvement of the isoform CtBP1-S/BARS50 in cellular membrane-trafficking processes and a role of the isoform RIBEYE as molecular scaffolds in ribbons, the presynaptic specializations of sensory synapses. CtBPs were suggested to regulate neuronal differentiation and they were implied in the control of gene expression during epileptogenesis. However, the expression patterns of CtBP family members in specific brain areas and their subcellular localizations in neurons in situ are largely unknown. Here, we performed comprehensive assessment of the expression of CtBP1 and CtBP2 in mouse brain at the microscopic and the ultra-structural levels using specific antibodies. We quantified and compared expression levels of both CtBPs in biochemically isolated brain fractions containing cellular nuclei or synaptic compartment. Our study demonstrates differential regional and subcellular expression patterns for the two CtBP family members in brain and reveals a previously unknown synaptic localization for CtBP2 in particular brain regions. Finally, we propose a mechanism of differential synapto-nuclear targeting of its splice variants CtBP2-S and CtBP2-L in neurons
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